Group
Sequential test Procedures included in version 3.0.
In a group sequential design there is at least one analysis (test of a hypothesis or confidence interval) performed before the planned final analysis. Data is collected until a pre-defined information level is achieved (for example a certain amount of data has been collected) and a test of the null-hypothesis is performed. If it turns out that the null-hypothesis is rejected at a pre-determined level of significance at the interim analysis, the testing stops, Otherwise more data is collected and a new analysis at the next interim analysis is performed. This process continues until either the null-hypothesis is rejected at an interim analysis or until one reaches the planned final analysis. Since there is more than one analysis performed of the same null-hypothesis, the p-values at the interim analyses and the final analysis have to be adjusted to control the pre-determined type I error by choosing one of the design option. |
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Test Procedures
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Design Options
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